CyclinD1 -| RB RB -> RB p53 -| RB ERBB2 -> RB TSC2 -| RB ERBB2 -> AKT AKT -> AKT stimulus -> AKT ERBB1 -> AKT PTEN -| AKT ERBB3 -> AKT CyclinB1 -| AKT cJUN -> CyclinD1 CyclinD1 -> CyclinD1 GSKa_b -| CyclinD1 AKT -> CyclinD1 ERK1_2 -> CyclinD1 PTEN -> CyclinD1 cJUN -> cJUN GSKa_b -| cJUN erlotinib -| ERBB1 stimulus -> ERBB1 pertuzumab -| ERBB1 ERBB1 -> ERBB1 AKT -| TSC2 GSKa_b -| TSC2 ERBB2 -> TSC2 ERK1_2 -| TSC2 TSC2 -> TSC2 AKT -| FoxO1_3a FoxO1_3a -> FoxO1_3a p53 -| CyclinB1 p70S6K -> CyclinB1 CyclinB1 -> CyclinB1 erlotinib -| ERBB2 ERBB2 -> ERBB2 BAX -> ERBB2 stimulus -> ERBB2 pertuzumab -| ERBB2 trastuzumab -| ERBB2 erlotinib -| ERBB3 AKT -| ERBB3 stimulus -> ERBB3 pertuzumab -| ERBB3 ERBB3 -> ERBB3 AKT -> p38 p38 -> p38 cRAF -> ERK1_2 ERK1_2 -> ERK1_2 ERBB1 -> ERK1_2 CyclinB1 -> ERK1_2 RPS6 -> RPS6 p70S6K -> RPS6 Nfkb -> Nfkb RPS6 -> Nfkb ERBB3 -> Nfkb GSKa_b -| PTEN p70S6K -> PTEN PTEN -> PTEN cRAF -> cRAF p53 -| cRAF ERBB2 -> cRAF RPS6 -> cRAF ERK1_2 -| cRAF ERBB1 -> cRAF p53 -> GSKa_b GSKa_b -> GSKa_b BAX -> BAX ERBB1 -> BAX AKT -| PRAS PRAS -> PRAS ERBB3 -> PRAS RB -> p53 p53 -> p53 CyclinB1 -> p53 PTEN -> p53 ERBB2 -> p70S6K PRAS -| p70S6K ERK1_2 -> p70S6K TSC2 -| p70S6K p70S6K -> p70S6K $AKT: (((((AKT & !(PTEN | CyclinB1)) | (ERBB1 & !(PTEN | CyclinB1))) | (ERBB2 & !(PTEN | CyclinB1))) | (ERBB3 & !(PTEN | CyclinB1))) | (stimulus & !(PTEN | CyclinB1))) $BAX: (BAX | ERBB1) $CyclinB1: ((p70S6K & !p53) | (CyclinB1 & !p53)) $CyclinD1: (((((ERK1_2 & !GSKa_b) | (PTEN & !GSKa_b)) | (CyclinD1 & !GSKa_b)) | (AKT & !GSKa_b)) | (cJUN & !GSKa_b)) $ERBB1: ((ERBB1 & !(pertuzumab | erlotinib)) | (stimulus & !(pertuzumab | erlotinib))) $ERBB2: (((BAX & !((erlotinib | trastuzumab) | pertuzumab)) | (ERBB2 & !((erlotinib | trastuzumab) | pertuzumab))) | (stimulus & !((erlotinib | trastuzumab) | pertuzumab))) $ERBB3: ((stimulus & !((erlotinib | AKT) | pertuzumab)) | (ERBB3 & !((erlotinib | AKT) | pertuzumab))) $ERK1_2: (((cRAF | ERK1_2) | CyclinB1) | ERBB1) $FoxO1_3a: (FoxO1_3a & !AKT) $GSKa_b: (p53 | GSKa_b) $Nfkb: ((ERBB3 | Nfkb) | RPS6) $PRAS: ((ERBB3 & !AKT) | (PRAS & !AKT)) $PTEN: ((p70S6K & !GSKa_b) | (PTEN & !GSKa_b)) $RB: ((RB & !((p53 | CyclinD1) | TSC2)) | (ERBB2 & !((p53 | CyclinD1) | TSC2))) $RPS6: (RPS6 | p70S6K) $TSC2: ((TSC2 & !((AKT | GSKa_b) | ERK1_2)) | (ERBB2 & !((AKT | GSKa_b) | ERK1_2))) $cJUN: (cJUN & !GSKa_b) $cRAF: ((((ERBB2 & !(ERK1_2 | p53)) | (cRAF & !(ERK1_2 | p53))) | (ERBB1 & !(ERK1_2 | p53))) | (RPS6 & !(ERK1_2 | p53))) $p38: (p38 | AKT) $p53: (((CyclinB1 | p53) | RB) | PTEN) $p70S6K: (((ERK1_2 & !(PRAS | TSC2)) | (ERBB2 & !(PRAS | TSC2))) | (p70S6K & !(PRAS | TSC2)))